Cancer - Awakening angels

被引：52

作者：

Lane, D ^{[1
]}

机构：

[1] Univ Dundee, Dept Biochem, Canc Res Campaign Labs, Dundee DD1 4HN, Scotland

来源：

NATURE | 1998年 / 394卷 / 6694期

关键词：

D O I：

10.1038/29166

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When mammalian cells are under stress they activate the tumour-suppressor gene p53. But how does the cell signal to p53 that it is under attack? A new study implicates the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage and can bind p53. Damaged cells that don't contain DNA-PK accumulate an inactive form of p53, indicating that DNA-PK is crucial for the activation of p53.

引用

页码：616 / 617

页数：2

共 14 条

[1] Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice
Araki, R
Fujimori, A
Hamatani, K
Mita, K
Saito, T
Mori, M
Fukumura, R
Morimyo, M
Muto, M
Itoh, M
Tatsumi, K
Abe, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2438 - 2443
[2] Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2
Blaydes, JP
Gire, V
Rowson, JM
WynfordThomas, D
[J]. ONCOGENE, 1997, 14 (15) : 1859 - 1868
[3] Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
Bottger, A
Bottger, V
Sparks, A
Liu, WL
Howard, SF
Lane, DP
[J]. CURRENT BIOLOGY, 1997, 7 (11) : 860 - 869
[4] THYMOCYTE APOPTOSIS INDUCED BY P53-DEPENDENT AND INDEPENDENT PATHWAYS
CLARKE, AR
PURDIE, CA
HARRISON, DJ
MORRIS, RG
BIRD, CC
HOOPER, ML
WYLLIE, AH
[J]. NATURE, 1993, 362 (6423) : 849 - 852
[5] p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice
Gurley, KE
Kemp, CJ
[J]. CARCINOGENESIS, 1996, 17 (12) : 2537 - 2542
[6] Mdm2 promotes the rapid degradation of p53
Haupt, Y
Maya, R
Kazaz, A
Oren, M
[J]. NATURE, 1997, 387 (6630) : 296 - 299
[7] A MAMMALIAN-CELL CYCLE CHECKPOINT PATHWAY UTILIZING P53 AND GADD45 IS DEFECTIVE IN ATAXIA-TELANGIECTASIA
KASTAN, MB
ZHAN, QM
ELDEIRY, WS
CARRIER, F
JACKS, T
WALSH, WV
PLUNKETT, BS
VOGELSTEIN, B
FORNACE, AJ
[J]. CELL, 1992, 71 (04) : 587 - 597
[8] KHANNA KK, 1993, ONCOGENE, V8, P3307
[9] Regulation of p53 stability by Mdm2
Kubbutat, MHG
Jones, SN
Vousden, KH
[J]. NATURE, 1997, 387 (6630) : 299 - 303
[10] HUMAN DNA-ACTIVATED PROTEIN-KINASE PHOSPHORYLATES SERINE-15 AND SERINE-37 IN THE AMINO-TERMINAL TRANSACTIVATION DOMAIN OF HUMAN P53
LEESMILLER, SP
SAKAGUCHI, K
ULLRICH, SJ
APPELLA, E
ANDERSON, CW
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (11) : 5041 - 5049

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