Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients

被引：80

作者：

Menges, T ^{[1
]}

Hermans, PWM

Little, SG

Langefeld, T

Böning, O

Engel, J

Sluijter, M

de Groot, R

Hempelmann, G

机构：

[1] Univ Giessen, Dept Anesthesiol & Intens Care Med, D-35385 Giessen, Germany

[2] Erasmus Univ, Sophia Childrens Hosp, Dept Pediat, Rotterdam, Netherlands

来源：

LANCET | 2001年 / 357卷 / 9262期

关键词：

D O I：

10.1016/S0140-6736(00)04311-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A single base pair insertion/deletion (4G/5G) promoter polymorphism in the plasminogen-activator-inhibitor-1 (PAI-1) gene is thought to play a part in prognosis after severe trauma. We investigated the relation between outcome of severe trauma, PAI-1 concentrations. and PAI-1 genotype in 61 patients who had been severely injured. 11 (58%) of 19 patients with genotype 4G/4G did not survive, whereas only eight (28%) of 29 patients with heterozygous genotype 4G/5G, and two (15%) of 13 patients with genotype 5G/5G died. The PAI-1 4G allele is associated with high concentrations of PAI-1 in plasma and a poor survival rate after severe trauma.

引用

页码：1096 / 1097

页数：2

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