Hydration of the phosphate group in double-helical DNA

被引：183

作者：

Schneider, B

Patel, K

Berman, HM

机构：

[1] Rutgers State Univ, Dept Chem, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA

[3] Acad Sci Czech Republ, J Heyrovsky Inst Phys Chem, CZ-18223 Prague, Czech Republic

来源：

BIOPHYSICAL JOURNAL | 1998年 / 75卷 / 05期

关键词：

D O I：

10.1016/S0006-3495(98)77686-6

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Water distributions around phosphate groups in 59 B-, A-, and Z-DNA crystal structures were analyzed. It is shown that the waters are concentrated in six hydration sites per phosphate and that the positions and occupancies of these sites are dependent on the conformation and type of nucleotide. The patterns of hydration that are characteristic of the backbone of the three DNA helical types can be attributed in part to the interactions of these hydration sites.

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页码：2422 / 2434

页数：13

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