Platelets and metastasis revisited:: a novel fatty link

被引：103

作者：

Gupta, GP

Massagué, J

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 12期

关键词：

D O I：

10.1172/JCI200423823

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis (see the related article beginning on page 1714).

引用

收藏

页码：1691 / 1693

页数：3

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