Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials

被引：92

作者：

Fields, RD ^{[1
]}

Lee, PR ^{[1
]}

Cohen, JE ^{[1
]}

机构：

[1] NICHD, Nervous Syst Dev & Plast Sect, NIH, Bethesda, MD 20892 USA

来源：

CELL CALCIUM | 2005年 / 37卷 / 05期

关键词：

calcium signaling; CREB; CaMKII; microarray; plasticity; DRG; intracellular signaling;

D O I：

10.1016/j.ceca.2005.01.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Temporal aspects of intracellular calcium signaling are particularly important in activity-dependent regulation of gene expression in neurons. This review traces calcium-dependent intracellular signaling from the membrane to the nucleus in response to action-potential firing, and considers how specific genes are regulated by specific patterns of impulse firing. Modes of calcium influx, calcium-dependent protein kinases, transcription factors, individual genes, and genomic analysis are examined, with particular emphasis on the importance of temporal aspects of calcium dynamics in regulating these processes. Published by Elsevier Ltd.

引用

页码：433 / 442

页数：10

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