Determination of serum levels of thirteen human immunodeficiency virus-suppressing drugs by high-performance liquid chromatography

被引：78

作者：

Simon, VA ^{[1
]}

Thiam, MD ^{[1
]}

Lipford, LC ^{[1
]}

机构：

[1] Dept Hlth, Jacksonville, FL 32202 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2001年 / 913卷 / 1-2期

关键词：

human immunodeficiency virus; enzyme inhibitors;

D O I：

10.1016/S0021-9673(00)01092-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two high-performance liquid chromatographic methods using UV detection are presented for the determination of two different groups (A and B) of drugs used in the suppression of human immunodeficiency virus (HIV). Group A is comprised of six nucleosidic reverse transcriptase inhibitors, viz. zalcitabine, lamivudine, stavudine, didanosine, zidovudine and ziagen. Group B consists of seven drugs four of which an protease inhibitors (PIs) and three of which are non-nucleosidic reverse transcriptase inhibitors (NNRTIs). The PIs are: indinavir, nelfinavir, saquinavir and ritonavir. The NNRTIs are: nevirapine, delavirdine and efavirenz. Groups A and El require separate aliquots of serum for extraction and must he chromatographed separately. (C) 2001 Elsevier Science BN. All rights reserved.

引用

页码：447 / 453

页数：7

共 6 条

[1]

ACOSTA E, 1999, MEDSCAPE HIV AIDS, V5

[2] Antiretroviral therapy for HIV infection in 1997 - Updated recommendations of the International AIDS Society USA panel [J].

Carpenter, CCJ ;

Fischl, MA ;

Hammer, SM ;

Hirsch, MS ;

Jacobsen, DM ;

Katzenstein, DA ;

Montaner, JSG ;

Richman, DD ;

Saag, MS ;

Schooley, RT ;

Thompson, MA ;

Vella, S ;

Yeni, PG ;

Volberding, PA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (24) :1962-1969

[3] Determination of saquinavir in human plasma, saliva, and cerebrospinal fluid by ion-pair high-performance liquid chromatography with ultraviolet detection [J].

Hoetelmans, RMW ;

vanEssenberg, M ;

Meenhorst, PL ;

Mulder, JW ;

Beijnen, JH .

JOURNAL OF CHROMATOGRAPHY B, 1997, 698 (1-2) :235-241

[4] Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir [J].

Kempf, DJ ;

Marsh, KC ;

Kumar, G ;

Rodrigues, AD ;

Denissen, JF ;

McDonald, E ;

Kukulka, MJ ;

Hsu, A ;

Granneman, GR ;

Baroldi, PA ;

Sun, E ;

Pizzuti, D ;

Plattner, JJ ;

Norbeck, DW ;

Leonard, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :654-660

[5]

Remmel RP, 2000, CLIN CHEM, V46, P73

[6]

USEPA, 1984, FED REGISTER, V49, P198

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