Regioselective glycosylation of 3,6-unprotected mannoside derivatives:: fast access to high-mannose type oligosaccharides

被引：18

作者：

Smiljanic, N ^{[1
]}

Halila, S ^{[1
]}

Moreau, V ^{[1
]}

Djedaïni-Pilard, F ^{[1
]}

机构：

[1] Univ Picardie, Lab Glucides, F-80039 Amiens, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 50期

关键词：

regioselective glycosylation; high-mannose;

D O I：

10.1016/j.tetlet.2003.09.219

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective glycosylation of 3,6-unprotected mannoside acceptors was investigated. With glycosyl trichloroacetimidate donors, when an excess of trimethylsilyl trifluoromethanesulfonate is used as the catalyst, 6-O-glycosylation exclusively occurred affording a silylated disaccharide that could be involved in a subsequent glycosylation reaction. As an illustration, the fast synthesis of two trisaccharides and one pentasaccharide was achieved. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8999 / 9002

页数：4

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[2]

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[3]

2-F

[4]

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