Tobacco and alcohol as risk factors for pancreatic cancer

被引：105

作者：

Korc, Murray ^{[1
,2
,3
,4
]}

Jeon, Christie Y. ^{[5
]}

Edderkaoui, Mouad ^{[6
]}

Pandol, Stephen J. ^{[6
]}

Petrov, Maxim S. ^{[7
]}

机构：

[1] Indiana Univ Sch Med, Dept Med, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Biochem, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Mol Biol, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA

[4] Pancreat Canc Signature Ctr, Indianapolis, IN USA

[5] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[6] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

[7] Univ Auckland, Dept Surg, Auckland, New Zealand

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2017年 / 31卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Pancreatic cancer; Tobacco; Alcohol; Population risk; Genetically engineered mouse models; LIFE-STYLE FACTORS; BODY-MASS INDEX; CIGARETTE-SMOKING; SYSTEMATIC ANALYSIS; PROSPECTIVE COHORT; STELLATE CELLS; GLOBAL BURDEN; POPULATION; MORTALITY; METAANALYSIS;

D O I：

10.1016/j.bpg.2017.09.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：529 / 536

页数：8

共 55 条

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