Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone

被引：64

作者：

Hulin, B

Newton, LS

Lewis, DM

Genereux, PE

Gibbs, EM

Clark, DA

机构：

[1] Central Research, Pfizer Inc., Groton, CT 06340, Eastern Point Road

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 20期

关键词：

D O I：

10.1021/jm960230h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg.

引用

页码：3897 / 3907

页数：11

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