Centrosomes and cilia in human disease

被引:276
作者
Bettencourt-Dias, Monica [1 ]
Hildebrandt, Friedhelm [2 ,3 ,4 ]
Pellman, David [5 ]
Woods, Geoff [6 ]
Godinho, Susana A. [5 ]
机构
[1] Inst Gulbenkian Ciencias, Oeiras, Portugal
[2] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA
[5] Harvard Univ, Dept Pediat Oncol, Howard Hughes Med Inst, Dana Farber Canc Inst,Childrens Hosp,Med Sch, Boston, MA 02115 USA
[6] Univ Cambridge, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 0XY, England
基金
欧洲研究理事会;
关键词
POLYCYSTIC KIDNEY-DISEASE; PLANAR CELL POLARITY; SENIOR-LOKEN-SYNDROME; CHROMOSOMAL INSTABILITY; DROSOPHILA NEUROBLASTS; CYST FORMATION; CANCER-CELLS; SPINDLE POLE; DAUGHTER CENTROSOME; GENETIC INSTABILITY;
D O I
10.1016/j.tig.2011.05.004
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Centrioles are microtubule-derived structures that are essential for the formation of centrosomes, cilia and flagella. The centrosome is the major microtubule organiser in animal cells, participating in a variety of processes, from cell polarisation to cell division, whereas cilia and flagella contribute to several mechanisms in eukaryotic cells, from motility to sensing. Although it was suggested more than a century ago that these microtubule-derived structures are involved in human disease, the molecular bases of this association have only recently been discovered. Surprisingly, there is very little overlap between the genes affected in the different diseases, suggesting that there are tissue-specific requirements for these microtubule-derived structures. Knowledge of these requirements and disease mechanisms has opened new avenues for therapeutical strategies. Here, we give an overview of recent developments in this field, focusing on cancer, diseases of brain development and ciliopathies.
引用
收藏
页码:307 / 315
页数:9
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