Anti-IL-23 and Anti-IL-17 Biologic Agents for the Treatment of Immune-Mediated Inflammatory Conditions

被引：67

作者：

Frieder, Jillian ^{[1
]}

Kivelevitch, Dario ^{[1
]}

Haugh, Isabel ^{[1
]}

Watson, Ian ^{[2
]}

Menter, Alan ^{[1
]}

机构：

[1] Baylor Scott & White, Div Dermatol, Dallas, TX 75201 USA

[2] Texas A&M Coll Med, Bryan, TX USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 103卷 / 01期

关键词：

SEVERE PLAQUE PSORIASIS; PLACEBO-CONTROLLED TRIAL; TO-SEVERE PSORIASIS; ANTI-INTERLEUKIN-23; MONOCLONAL-ANTIBODY; REMITTING MULTIPLE-SCLEROSIS; ACTIVE RHEUMATOID-ARTHRITIS; SEVERE CROHNS-DISEASE; DOUBLE-BLIND; PHASE-III; SUBCUTANEOUS IXEKIZUMAB;

D O I：

10.1002/cpt.893

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Advancements in the immunopathogenesis of psoriasis have identified interleukin (IL)-23 and IL-17 as fundamental contributors in the immune pathways of the disease. Leveraging these promising therapeutic targets has led to the emergence of a number of anti-IL-23 and -17 biologic agents with the potential to treat multiple conditions with common underlying pathology. The unprecedented clinical efficacy of these agents in the treatment of psoriasis has paved way for their evaluation in diseases such as psoriatic arthritis, Crohn's disease, rheumatoid arthritis, in addition to other immune-mediated conditions. Here we review the IL-23/IL-17 immune pathways and discuss the key clinical and safety data of the anti-IL-23 and anti-IL-17 biologic agents in psoriasis and other immune-mediated diseases.

引用

页码：88 / 101

页数：14

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