Cytokine cross-talk between mother and the embryo/placenta

Cytokines are regulatory glycoproteins that can affect virtually every cell type in the body and have pleiotropic regulatory effects on hematopoietic, endocrine, nervous and immune systems. Chemokines, although considered as members of the cytokine superfamily, are establishing their own identity. Chemokines mediate leukocyte migration through specific G protein coupled receptors in various tissues. Recently, much evidence has suggested that cytokines and chemokines play a very important role in the reproduction, i.e. embryo implantation, endometrial development, and trophoblast growth and differentiation by modulating the immune and endocrine systems. The close correlation between the embryo and endometrium and between the placenta and decidua are mediated by sex steroid hormones, cytokines and chemokines. As a result of this closely related cross-talk, pregnancy is successfully maintained. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.