Signaling T-cell survival and death by IL-2 and IL-15

被引：45

作者：

Zambricki, E

Shigeoka, A

Kishimoto, H

Sprent, J

Burakoff, S

Carpenter, C

Milford, E

McKay, D ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] NYU, Sch Med, Skirball Inst Biomol Med, Dept Med, New York, NY USA

[3] NYU, Sch Med, Skirball Inst Biomol Med, Dept Pediat, New York, NY USA

[4] NYU, Sch Med, Skirball Inst Biomol Med, Dept Pathol, New York, NY USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Nephrol, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2005年 / 5卷 / 11期

关键词：

cytokines; cytokine receptors; signal transduction; T cells; transplantation;

D O I：

10.1111/j.1600-6143.2005.01075.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Interleukin 2 (IL-2) and interleukin 15 (IL-15) bind to common T-cell surface receptors comprised of unique alpha (IL-2R alpha or IL-15R alpha) and shared beta/gamma chain subunits. Ligation of this receptor by IL-2 can lead to apoptosis whereas IL-15 ligation favors cell survival. Our study examined intra-cellular signaling events associated with IL-2- and IL-15-induced apoptosis and survival in human T cells. We found IL-2 and IL-15 could both induce apoptosis and survival; the outcome depended on cytokine concentration. No qualitative differences in Jak/Stat, Ras/MAPK or PI3K/AKT signaling were seen over a wide range of IL-2 and IL-15 concentrations. These findings suggest that, like T-cell receptor signaling, IL-2R beta/gamma chain signaling is regulated, or "tuned," by the concentration of cytokine.

引用

页码：2623 / 2631

页数：9

共 55 条

[1] Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase [J].