Serum amyloid A concentration is increased in obese children and adolescents

被引:18
作者
Gomez-Ambrosi, Javier [2 ,4 ]
Azcona, Cristina [3 ]
Patino-Garcia, Ana [3 ]
Fruhbeck, Gema [1 ,2 ,4 ]
机构
[1] Univ Navarra, Univ Navarra Clin, Dept Endocrinol, Pamplona, Spain
[2] Univ Navarra, Univ Navarra Clin, Metab Res Lab, Pamplona, Spain
[3] Univ Navarra, Univ Navarra Clin, Dept Pediat, Pamplona, Spain
[4] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain
关键词
D O I
10.1016/j.jpeds.2008.01.006
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To compare the circulating concentrations of the acute-phase protein serum amyloid A (SAA) in lean, overweight, and obese children and adolescents and analyze the influence of body fat. Study design A total of 63 children and adolescents (65% girls) with an average age of 12.1 +/- 2.7 years (range, 6 to 18 years) were included in the study. Each child was classified on the basis of age- and sex-specific body mass index (BMI) percentile as normal weight (BMI < 85th percentile; n = 17), overweight (BMI >= 85th and < 95th percentiles; n = 26), or obese (BMI >= 95th percentile; n = 20). Body fat was estimated by air-displacement plethysmography. Results Both overweight and obese children exhibited significantly increased circulating SAA concentrations (log SAA: lean, 0.66 +/- 0.20; overweight, 0.83 +/- 0.29; obese, 0.96 +/- 0.21; P =.002) compared with the lean children. Significant correlations were found between log SAA and body fat (r = 0.48; P <.0001). In multiple linear regression analysis, log C-reactive protein (CRP) (P =.014) and body fat (P =.031) emerged as significant predictors of log SAA. Conclusions Plasma SAA concentrations are elevated in overweight and obese children, being strongly related to adiposity and log CRP. This finding suggests that increased body fat may contribute to the development of a low-grade chronic proinflammatory state at an early age, possibly contributing to the obesity-associated cardiovascular disease risk.
引用
收藏
页码:71 / 75
页数:5
相关论文
共 31 条
[1]   Fat mass by air-displacement plethysmography and impedance in obese/non-obese children and adolescents [J].
Azcona, Cristina ;
Koeek, Nadia ;
Fruehbeck, Gema .
INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY, 2006, 1 (03) :176-182
[2]   Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree [J].
Connelly, PW ;
Hanley, AJ ;
Harris, SB ;
Hegele, RA ;
Zinman, B .
INTERNATIONAL JOURNAL OF OBESITY, 2003, 27 (03) :347-354
[3]   Risk factors for coronary heart disease and acute-phase proteins - A population-based study [J].
Danesh, J ;
Muir, J ;
Wong, YK ;
Ward, M ;
Gallimore, JR ;
Pepys, MB .
EUROPEAN HEART JOURNAL, 1999, 20 (13) :954-959
[4]   Discriminative value of serum amyloid A and other acute-phase proteins for coronary heart disease [J].
Delanghe, JR ;
Langlois, MR ;
De Bacquer, D ;
Mak, R ;
Capel, P ;
Van Renterghem, LV ;
De Backer, G .
ATHEROSCLEROSIS, 2002, 160 (02) :471-476
[5]  
Economou EV, 2005, MEDIAT INFLAMM, P337, DOI 10.1155/MI.2005.337
[6]  
Elberg J, 2004, AM J CLIN NUTR, V80, P64
[7]   Air-displacement plethysmography: here to stay [J].
Fields, DA ;
Higgins, PB ;
Radley, D .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2005, 8 (06) :624-629
[8]   Hunting for new pieces to the complex puzzle of obesity [J].
Fruhbeck, Gema .
PROCEEDINGS OF THE NUTRITION SOCIETY, 2006, 65 (04) :329-347
[9]   Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass [J].
Gómez-Ambrosi, J ;
Salvador, J ;
Rotellar, F ;
Silva, C ;
Catalán, V ;
Rodríguez, A ;
Gil, MJ ;
Frühbeck, G .
OBESITY SURGERY, 2006, 16 (03) :262-269
[10]  
Gunczler P, 2006, J PEDIATR ENDOCR MET, V19, P259