Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis

被引：34

作者：

Ide, Hisamitsu ^{[1
]}

Hatake, Kiyohiko ^{[3
]}

Terado, Yuichi ^{[2
]}

Tsukino, Hiroyuki ^{[4
]}

Okegawa, Takatsugu ^{[5
]}

Nutahara, Kikuo ^{[5
]}

Higashihara, Eiji ^{[5
]}

Horie, Shigeo ^{[1
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Urol, Itabashi Ku, Tokyo 1738605, Japan

[2] Kyorin Univ, Sch Med, Dept Pathol, Mitaka, Tokyo 181, Japan

[3] Japanese Fdn Canc Res, Dept Med Oncol, Canc Inst Hosp, Koutou Ku, Mitaka, Tokyo, Japan

[4] Miyazaki Univ, Dept Urol, Sch Med, Miyazaki, Japan

[5] Kyorin Univ, Sch Med, Dept Urol, Mitaka, Tokyo 181, Japan

来源：

HUMAN CELL | 2008年 / 21卷 / 01期

关键词：

bone metastasis; macrophage colony-stimulating factor; prostate cancer;

D O I：

10.1111/j.1749-0774.2007.00042.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Recent evaluation of human prostate tissues has shown predominantly high expression of the macrophage colony-stimulating factor receptor in prostatic intra-epithelial neoplasia or prostate cancer. However, the expression of its ligand, the macrophage colony-stimulating factor (M-CSF), and the biological role of this signaling in prostate cancer has not been analyzed. In this research we determined the relationship of serum M-CSF level to clinical parameters of prostate cancer progression. We measured the serum level of M-CSF in 170 patients with histologically confirmed prostatic adenocarcinoma and in 54 patients in whom prostate cancer was not detected. We also investigated the M-CSF expression in prostate cancer tissues by immunohistochemistry. The serum levels of M-CSF in bone metastatic prostate cancer patients was significantly higher than those in non-metastatic patients, while M-CSF did not differ with regards to histological grade, Gleason score or local tumor progression. M-CSF expression was detected in prostate cancer cells themselves by immunohistochemistry. These results suggest that M-CSF may have a functional role in prostate cancer progression.

引用

页码：1 / 6

页数：6

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