The natural substrate for nitric oxide synthase activity

被引：16

作者：

Alaghband-Zadeh, J ^{[1
]}

Mehdizadeh, S ^{[1
]}

Khan, NS ^{[1
]}

O'Farrell, A ^{[1
]}

Bitensky, L ^{[1
]}

Chayen, J ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Clin Chem, London W6 8RP, England

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2001年 / 19卷 / 04期

关键词：

carnosine; nitric oxide synthase; cryostat sections; microdensitometery;

D O I：

10.1002/cbf.930

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There has been little evidence to indicate that arginine is the natural substrate for generating nitric oxide synthase (NOS) activity. It is now shown that carnosine, which is widely distributed in tissues, is likely to be the true substrate. In tissue sections it gives a stronger NOS reaction than does arginine. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：277 / 280

页数：4

共 10 条

[1] AVENA RM, 1969, J BIOL CHEM, V244, P1600
[2] INCREASED MYOSIN ORIENTATION DURING MUSCLE-CONTRACTION - A MEASURE OF CARDIAC CONTRACTILITY
CHAYEN, J
BITENSKY, L
BRAIMBRIDGE, MV
DARRACOTTCANKOVIC, S
[J]. CELL BIOCHEMISTRY AND FUNCTION, 1985, 3 (02) : 101 - 114
[3] Chayen J, 1991, PRACTICAL HISTOCHEMI
[4] CHAYEN J, 1980, MONOGRAPHS ENDOCRINO
[5] THE SIGNIFICANCE OF CARNOSINE AND ANSERINE IN STRIATED SKELETAL MUSCLE
DAVEY, CL
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1960, 89 (02) : 303 - 308
[6] LONG C, 1961, BIOCHEMIST HANDBOOK, P668
[7] HISTOCHEMISTRY OF GUANYLATE-CYCLASE ACTIVITY
MEHDIZADEH, S
OFARRELL, A
BITENSKY, L
WEISZ, J
ALAGHBANDZADEH, J
CHAYEN, J
[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1995, 43 (12) : 1235 - 1240
[8] BIOSYNTHESIS OF NITRIC-OXIDE FROM L-ARGININE - A PATHWAY FOR THE REGULATION OF CELL-FUNCTION AND COMMUNICATION
MONCADA, S
PALMER, RMJ
HIGGS, EA
[J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) : 1709 - 1715
[9] VASCULAR ENDOTHELIAL-CELLS SYNTHESIZE NITRIC-OXIDE FROM L-ARGININE
PALMER, RMJ
ASHTON, DS
MONCADA, S
[J]. NATURE, 1988, 333 (6174) : 664 - 666
[10] STUEHR DJ, 1992, ADV ENZYMOL, V65, P287

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