Molecular and epidemiologic analysis of dengue virus isolates from Somalia

被引：33

作者：

Kanesa-thasan, N

Chang, GJJ

Smoak, BL

Magill, A

Burrous, MJ

Hoke, CH

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Virus Dis, DCD&I, Washington, DC 20307 USA

[2] Ctr Dis Control & Prevent, Ft Collins, CO USA

来源：

EMERGING INFECTIOUS DISEASES | 1998年 / 4卷 / 02期

关键词：

D O I：

10.3201/eid0402.980220

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nucleotide sequence analysis was performed on 14 dengue virus isolates (13 dengue-2 viruses and 1 dengue-3 virus) recovered from febrile soldiers in Somalia in 1993. The dengue-e viruses were most closely related to dengue-2 virus recovered in Somalia in 1984. However, differences in nucleotide sequence (0.35% to 1.35%) were evident among the 1993 isolates. These differences were closely associated with the geographic location of the infection as well as with different times of infection at the same location. Genetic difference between strains was not associated with differences in clinical features. Molecular analysis of dengue viruses is a useful adjunct to epidemiologic investigation of their distribution over distance and time.

引用

页码：299 / 303

页数：5

共 12 条

[1]

BURKE DS, 1997, EMERG INFECT DIS, V3, P153

[2]

Felsenstein J, 1993, PHYLIP (Phylogeny Inference Package) version 3.5c

[3] MOSQUITO CELL-CULTURES AND SPECIFIC MONOCLONAL-ANTIBODIES IN SURVEILLANCE FOR DENGUE VIRUSES [J].