Adrenergic airway vascular smooth muscle responsiveness in healthy and asthmatic subjects

被引:36
作者
Brieva, J [1 ]
Wanner, A [1 ]
机构
[1] Univ Miami, Mt Sinai Med Ctr, Sch Med, Div Pulm & Crit Care Med, Miami Beach, FL 33140 USA
关键词
bronchial blood flow; asthma; adrenergic agonists;
D O I
10.1152/jappl.2001.90.2.665
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The purpose of the present study was to determine the responsiveness of airway vascular smooth muscle (AVSM) as assessed by airway mucosal blood flow ((Q) over dotaw) to inhaled methoxamine (alpha (1)-agonist; 0.6-2.3 mg) and albuterol (beta (2)-agonist; 0.2-1.2 mg) in healthy [n = 11; forced expiratory volume in 1 s, 92 +/- 4 (SE) % of predicted] and asthmatic (n = 11, mean forced expiratory volume in 1 s, 81 +/- 5%) adults. Mean baseline values for (Q) over dotaw were 43.8 +/- 0.7 and 54.3 +/- 0.8 mul.min(-1).ml(-1) of anatomic dead space in healthy and asthmatic subjects, respectively (P < 0.05). After methoxamine inhalation, the maximal mean change in (Q) over dotaw was -13.5 +/- 1.0 <mu>l.min(-1).ml(-1) in asthmatic and -7.1 +/- 2.1 mul.min(-1).ml(-1) in healthy subjects (P < 0.05). After albuterol, the mean maximal change in (Q) over dotaw was 3.0 +/- 0.8 <mu>l.min(-1).ml(-1) in asthmatic and 14.0 +/- 1.1 mul.min(-1).ml(-1) in healthy subjects (P < 0.05). These results demonstrate that the contractile response of AVSM to <alpha>(1)-adrenoceptor activation is enhanced and the dilator response of AVSM to beta (2)-adrenoceptor activation is blunted in asthmatic subjects.
引用
收藏
页码:665 / 669
页数:5
相关论文
共 28 条
[1]  
[Anonymous], 1987, AM REV RESPIR DIS, V136, P225
[2]  
BARNES PJ, 1986, AM REV RESPIR DIS, V134, P1289
[3]   INCREASED PULMONARY ALPHA-ADRENERGIC AND REDUCED BETA-ADRENERGIC RECEPTORS IN EXPERIMENTAL ASTHMA [J].
BARNES, PJ ;
DOLLERY, CT ;
MACDERMOT, J .
NATURE, 1980, 285 (5766) :569-571
[4]   DOSE-RESPONSE CURVES TO INHALED BETA-ADRENOCEPTOR AGONISTS IN NORMAL AND ASTHMATIC SUBJECTS [J].
BARNES, PJ ;
PRIDE, NB .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 15 (06) :677-682
[5]   HUMAN-LUNG ADRENORECEPTORS STUDIED BY RADIOLIGAND BINDING [J].
BARNES, PJ ;
KARLINER, JS ;
DOLLERY, CT .
CLINICAL SCIENCE, 1980, 58 (06) :457-461
[6]   CIRCADIAN VARIATION IN ADRENERGIC RESPONSES IN ASTHMATIC SUBJECTS [J].
BARNES, PJ ;
FITZGERALD, GA ;
DOLLERY, CT .
CLINICAL SCIENCE, 1982, 62 (04) :349-354
[7]   THE ACTION OF PRAZOSIN AND PROPYLENE-GLYCOL ON METHOXAMINE-INDUCED BRONCHOCONSTRICTION IN ASTHMATIC SUBJECTS [J].
BLACK, JL ;
SALOME, C ;
YAN, K ;
SHAW, J .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 18 (03) :349-353
[8]   Effect of an inhaled glucocorticosteroid on airway mucosal blood flow in mild asthma [J].
Brieva, JL ;
Danta, I ;
Wanner, A .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (01) :293-296
[9]  
CARSTAIRS JR, 1985, AM REV RESPIR DIS, V132, P541
[10]   Effect of aerosolized acetylcholine on bronchial blood flow [J].
Charan, NB ;
Carvalho, P ;
Johnson, SR ;
Thompson, WH ;
Lakshminarayan, S .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 85 (02) :432-436