Single-chain immunotoxins targeted to CD40 for the treatment of human B-lineage hematologic malignancies

被引：5

作者：

Francisco, JA ^{[1
]}

Siegall, CB ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Dept Mol Immunol, Seattle, WA 98121 USA

来源：

LEUKEMIA & LYMPHOMA | 1998年 / 30卷 / 3-4期

关键词：

single-chain immunotoxins; CD40; treatment; human-B-lineage malignancy;

D O I：

10.3109/10428199809057537

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunotoxins, in chemical conjugate form, have shown limited efficacy in clinical trials in patients with hematologic malignancies. Single-chain immunotoxins (SCIT) provide for enhanced therapeutic efficacy over chemical conjugate forms without additional toxicity and thus may result in improved antitumor activity. We have evaluated two SCITs targeted to CD40, a receptor expressed on most B-lineage hematologic malignancies, for the treatment of non-Hodgkin's lymphoma and multiple myeloma. Both SCITs, G28-5 sFv-PE40 and BD1-G28-5 sFv, were highly potent and specifically cytotoxic against non-Hodgkin's lymphoma and multiple myeloma cell lines. G28-5 sFv-PE40 has proven to be efficacious in SCID mice bearing human non-Hodgkin's lymphoma and multiple myeloma xenografts. Antitumor activity has also been noted in preliminary studies using BD1-G28-5 sFv in non-Hodgkin's lymphoma models. The data presented here indicate that these agents should be considered for use in clinical trials in patients with refractive non-Hodgkin's lymphoma, multiple myeloma and other CD40-expressing hematologic malignancies.

引用

页码：237 / 245

页数：9

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