Bioinformatic analysis suggests potential mechanisms underlying parasitoid venom evolution and function

被引：16

作者：

Alvarado, Gloria ^{[1
]}

Holland, Sarah R. ^{[1
]}

DePerez-Rasmussen, Jordan ^{[1
]}

Jarvis, Brice A. ^{[1
]}

Telander, Tyler ^{[1
]}

Wagner, Nicole ^{[1
]}

Waring, Ashley L. ^{[1
]}

Anast, Anissa ^{[1
]}

Davis, Bria ^{[1
]}

Frank, Adam ^{[1
]}

Genenbacher, Katelyn ^{[1
]}

Larson, Josh ^{[1
]}

Mathis, Corey ^{[1
]}

Oates, A. Elizabeth ^{[1
]}

Rhoades, Nicholas A. ^{[1
]}

Scott, Liz ^{[1
]}

Young, Jamie ^{[1
]}

Mortimer, Nathan T. ^{[1
]}

机构：

[1] Illinois State Univ, Sch Biol Sci, Normal, IL 61761 USA

来源：

GENOMICS | 2020年 / 112卷 / 02期

关键词：

WASP NASONIA-VITRIPENNIS; KETOGLUTARATE DEHYDROGENASE COMPLEX; IMMUNE-RESPONSE; DROSOPHILA-MELANOGASTER; PYRUVATE-DEHYDROGENASE; LEPTOPILINA-BOULARDI; SARCOPHAGA-BULLATA; HOST-DEFENSE; FLESH FLY; ANTIVIRAL AUTOPHAGY;

D O I：

10.1016/j.ygeno.2019.06.022

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Hymenopteran parasitoid wasps are a diverse collection of species that infect arthropod hosts and use factors found in their venoms to manipulate host immune responses, physiology, and behaviour. Whole parasitoid venoms have been profiled using proteomic approaches, and here we present a bioinformatic characterization of the venom protein content from Ganaspis sp. 1, a parasitoid that infects flies of the genus Drosophila. We find evidence that diverse evolutionary processes including multifunctionalization, co-option, gene duplication, and horizontal gene transfer may be acting in concert to drive venom gene evolution in Ganaspis sp.1. One major role of parasitoid wasp venom is host immune evasion. We previously demonstrated that Ganaspis sp. 1 venom inhibits immune cell activation in infected Drosophila melanogaster hosts, and our current analysis has uncovered additional predicted virulence functions. Overall, this analysis represents an important step towards understanding the composition and activity of parasitoid wasp venoms.

引用

页码：1096 / 1104

页数：9

共 120 条

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