Role reversal: new insights from new ligands for the xenobiotic receptor CAR

被引：53

作者：

Tzameli, I

Moore, DD

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol & Metab, Boston, MA 02215 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2001年 / 12卷 / 01期

关键词：

D O I：

10.1016/S1043-2760(00)00332-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the classic model of nuclear receptor signaling, specific hormone binding results in the recruitment of coactivator proteins and transcriptional activation. Recent results with newly characterized nuclear receptors have expanded this model to include new types of ligands and novel transcriptional responses. Both inverse agonists and conventional agonist ligands have been identified for the xenobiotic receptor constitutive androstane receptor (CAR), a constitutive activator of transcription in the absence of ligands.

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页码：7 / 10

页数：4

相关论文

共 31 条

[1]

Auwerx J, 1999, CELL, V97, P161

[2] A NEW ORPHAN MEMBER OF THE NUCLEAR HORMONE-RECEPTOR SUPERFAMILY THAT INTERACTS WITH A SUBSET OF RETINOIC ACID RESPONSE ELEMENTS [J].

BAES, M ;

GULICK, T ;

CHOI, HS ;

MARTINOLI, MG ;

SIMHA, D ;

MOORE, DD .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) :1544-1552

[3]

BANNER CD, 1993, J LIPID RES, V34, P1583

[4] SXR, a novel steroid and xenobiotic-sensing nuclear receptor [J].

Blumberg, B ;

Sabbagh, W ;

Juguilon, H ;

Bolado, J ;

van Meter, CM ;

Ono, ES ;

Evans, RM .

GENES & DEVELOPMENT, 1998, 12 (20) :3195-3205

[5] Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR [J].

Choi, HS ;

Chung, MR ;

Tzameli, I ;

Simha, D ;

Lee, YK ;

Seol, W ;

Moore, DD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) :23565-23571

[6] Androstane metabolites bind to and deactivate the nuclear receptor CAR-β [J].

Forman, BM ;

Tzameli, I ;

Choi, HS ;

Chen, L ;

Simha, D ;

Seol, W ;

Evans, RM ;

Moore, DD .

NATURE, 1998, 395 (6702) :612-615

[7] Orphan nuclear receptors:: From gene to function [J].

Giguère, V .

ENDOCRINE REVIEWS, 1999, 20 (05) :689-725

[8] FATTY-ACIDS ACTIVATE A CHIMERA OF THE CLOFIBRIC ACID-ACTIVATED RECEPTOR AND THE GLUCOCORTICOID RECEPTOR [J].

GOTTLICHER, M ;

WIDMARK, E ;

LI, Q ;

GUSTAFSSON, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4653-4657

[9] The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene [J].

Honkakoski, P ;

Zelko, I ;

Sueyoshi, T ;

Negishi, M .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (10) :5652-5658

[10] The pregnane x receptor: A promiscuous xenobiotic receptor that has diverged during evolution [J].

Jones, SA ;

Moore, LB ;

Shenk, JL ;

Wisely, GB ;

Hamilton, GA ;

McKee, DD ;

Tomkinson, NCO ;

LeCluyse, EL ;

Lambert, MH ;

Willson, TM ;

Kliewer, SA ;

Moore, JT .

MOLECULAR ENDOCRINOLOGY, 2000, 14 (01) :27-39

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