Validating Stat3 in cancer therapy

被引：267

作者：

Darnell, JE ^{[1
]}

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

来源：

NATURE MEDICINE | 2005年 / 11卷 / 06期

关键词：

D O I：

10.1038/nm0605-595

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factor STAT3 is overactive in many tumors and has attracted attention as a drug target. But in vivo evidence suggesting that inhibiting STAT3 could counteract cancer has been incomplete. The picture in the whole animal now begins to clarify, and it bodes well for this approach ( pages 623 - 629).

引用

页码：595 / 596

页数：2

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