An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent

被引：27

作者：

Tomoda, A

Arai, S

Ishida, R

Shimamoto, T

Ohyashiki, K

机构：

[1] Tokyo Med Univ, Dept Biochem, Shinjuku Ku, Tokyo 1608402, Japan

[2] Tokyo Med Univ, Dept Chem, Shinjuku Ku, Tokyo 1608402, Japan

[3] Aichi Canc Ctr, Res Inst, Chikusa Ku, Nagoya, Aichi 4640021, Japan

[4] Tokyo Med Univ, Dept Internal Med, Shinjuku Ku, Tokyo 1600023, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00153-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and rapid preparation method for a novel antitumor agent, 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one (Phx) was described. The procedure included (1) the reaction of bovine hemolysates with 2-amino-5-methylphenol. (2) one-shot denaturation of hemoglobin and proteins by methanol. and removal of the denatured hemoglobin and proteins. (3) concentration of the reaction products. and (4) purification by a Sephadex column. These procedures yielded Ph in 34% yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1057 / 1058

页数：2

共 8 条

[1] DIFFERENCES IN THE REACTIONS OF ISOMERIC ORTHO-AMINOPHENOLS AND PARA-AMINOPHENOLS WITH HEMOGLOBIN [J].