The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release

被引：15

作者：

Nail-Boucherie, K

Dourmap, N

Jaffard, R

Costenin, J

机构：

[1] Fac Med & Pharm Rouen, IFRMP 23, ESA 6036 CNRS, Unite Neuropsychopharmacol Expt, F-76803 St Etienne, France

[2] Univ Bordeaux 1, Lab Neurosci Comportementales & Cognit, URA 339 CNRS, F-33405 Talence, France

来源：

COGNITIVE BRAIN RESEARCH | 1998年 / 7卷 / 02期

关键词：

dopamine uptake inhibitor; acetylcholine release; hippocampus; muscarinic receptor antagonist; passive avoidance test; rat;

D O I：

10.1016/S0926-6410(98)00023-8

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

The specific dopamine uptake inhibitor, GBR 12783 was tested on the retention performance of a one-trial passive avoidance test. For a moderate electric shock intensity, GBR 12783 (10 mg/kg), injected before acquisition session, improved retention performance. Scopolamine (0.125-0.5 mg/kg) completely blocked the promnesic effect of GBR 12783. Moreover, GBR 12783 increased hippocampal acetylcholine release in vivo. These data suggest that the promnesic effect of GBR 12783 is mediated by an increase in the septo-hippocampal cholinergic transmission. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：203 / 205

页数：3

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