Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region

被引：51

作者：

Holroyd, KJ

Martinati, LC

Trabetti, E

Scherpbier, T

Eleff, SM

Boner, AL

Pignatti, PF

Kiser, MB

Dragwa, CR

Hubbard, F

Sullivan, CD

Grasso, L

Messler, CJ

Huang, MX

Hu, Y

Nicolaides, NC

Buetow, KH

Levitt, RC

机构：

[1] Magainin Pharmaceut, Magainin Inst Mol Med, Plymouth Meeting, PA 19462 USA

[2] Univ Verona, Inst Biol & Genet, I-37100 Verona, Italy

[3] Univ Verona, Dept Pediat, I-37100 Verona, Italy

[4] Fox Chase Canc Ctr, Div Populat Sci, Philadelphia, PA 19111 USA

[5] Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA

来源：

GENOMICS | 1998年 / 52卷 / 02期

关键词：

D O I：

10.1006/geno.1998.5445

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate. (C) 1998 Academic Press.

引用

页码：233 / 235

页数：3

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