Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors

被引：75

作者：

Finn, J ^{[1
]}

Mattia, K ^{[1
]}

Morytko, M ^{[1
]}

Ram, S ^{[1
]}

Yang, YF ^{[1
]}

Wu, XM ^{[1
]}

Mak, E ^{[1
]}

Gallant, P ^{[1
]}

Keith, D ^{[1
]}

机构：

[1] Cubist Pharmaceut Inc, Lexington, MA 02421 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(03)00298-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Starting with a micromolar lead identified from high-throughput screening, a series of pyrazoles were discovered with significanty improved potency on bacterial methionyl-tRNA synthetase and selectivity over human methionyl-tRNA synthetase. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：2231 / 2234

页数：4

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