Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

被引：250

作者：

Hodgkin, MN ^{[1
]}

Pettitt, TR

Martin, A

Michell, RH

Pemberton, AJ

Wakelam, MJO

机构：

[1] Univ Birmingham, Inst Canc Studies, Birmingham B15 2TA, W Midlands, England

[2] Univ Birmingham, Sch Biochem, Birmingham B15 2TT, W Midlands, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(98)01200-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate-specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.

引用

页码：200 / 204

页数：5

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