Dosing in obesity: A simple solution to a big problem

被引：176

作者：

Han, P. Y.

Duffull, S. B.

Kirkpatrick, C. M. J.

Green, B. ^{[1
]}

机构：

[1] Univ Queensland, Sch Pharm, Brisbane, Qld, Australia

[2] Univ Otago, Sch Pharm, Dunedin, New Zealand

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 05期

关键词：

D O I：

10.1038/sj.clpt.6100381

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The global epidemic of obesity has led to an increased prevalence of chronic diseases and need for pharmacological intervention. However, little is known about the influence of obesity on the drug-exposure profile, resulting in few clear dosing guidelines for the obese. Here we present a semi- mechanistic model for lean body weight (LBW) that we believe is sufficiently robust to quantify the influence of body composition on drug clearance, and is therefore an ideal metric for adjusting chronic dosing in the obese.

引用

页码：505 / 508

页数：5

共 14 条

[1]

[Anonymous], 2006, Global Database on Body Mass Index

[2]

[Anonymous], 1976, RES OBESITY

[3]

[Anonymous], 2004, INN STAGN CHALL OPP

[4] GENTAMICIN THERAPY [J].