Phospholipase A2

被引：95

作者：

Diaz, BL

Arm, JP

机构：

[1] INCA, Inst Nacl Canc, Div Biol Celular, BR-20231050 Rio De Janeiro, Brazil

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[4] Partners Asthma Ctr, Boston, MA 02115 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2003年 / 69卷 / 2-3期

关键词：

phospholipase A(2); arachidonic acid; eicosanoids; inflammation; cancer;

D O I：

10.1016/S0952-3278(03)00069-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA(2) enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：87 / 97

页数：11

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