B7-H1 connection of innate and adaptive immunity against tumor dormancy

被引：4

作者：

Chen, LP ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA

来源：

BLOOD | 2005年 / 105卷 / 06期

关键词：

D O I：

10.1182/blood-2004-12-4845

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dormant leukemia cells are selected to express B7-H1 and become resistant to T cells, whereas their susceptibility to NK cells remains intact. In contrast, NK cells expressing 137-H1 stimulate T-cell activation, which in turn keeps NK cells active. As a consequence, NK cells become the major player in eradicating dormant leukemia cells.

引用

页码：2242 / 2243

页数：2

共 4 条

[1] Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity [J].