Murine Cecal Patch M Cells Transport Infectious Prions In Vivo

被引：17

作者：

Foster, Neil ^{[1
]}

Macpherson, Gordon G. ^{[2
]}

机构：

[1] Univ Nottingham, Sch Vet Med & Sci, Nottingham NG7 2NR, England

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 12期

关键词：

SCRAPIE AGENT NEUROINVASION; CREUTZFELDT-JAKOB-DISEASE; PEYERS-PATCHES; INTESTINE; GENOTYPE; PROTEIN;

D O I：

10.1086/657415

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.

引用

页码：1916 / 1919

页数：4

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