HLA supertypes and supermotifs: a functional perspective on HLA polymorphism

被引：191

作者：

Sette, A ^{[1
]}

Sidney, J ^{[1
]}

机构：

[1] Epimmune Inc, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(98)80124-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A large fraction of HLA class I, and possibly class II, molecules can be classified into relatively few supertypes, characterized by overlapping peptide-binding repertoires and consensus B- and F-pocket structures. Cross-binding peptides are frequently recognized by specific T cells in the course of natural disease processes and in the context of multiple HLA molecules, validating the concept of HLA supertypes at the functional level.

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收藏

页码：478 / 482

页数：5

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