Determination of non-steroidal anti-inflammatory drugs in surface water and wastewater by liquid chromatography-tandem mass spectrometry

被引：66

作者：

Marchese, S ^{[1
]}

Perret, D ^{[1
]}

Gentili, A ^{[1
]}

Curini, R ^{[1
]}

Pastori, F ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, Lab Chim Sicurezza, I-00185 Rome, Italy

来源：

CHROMATOGRAPHIA | 2003年 / 58卷 / 5-6期

关键词：

column liquid chromatography; mass spectrometry detection; analgesics; salicylic acid; surface water analysis;

D O I：

10.1365/s10337-003-0052-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics: Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac and the decomposition product of acetylsalicylic acid: salicylic acid. The selected compounds are acidic, very polar and all are analgesic compounds that can be purchased without medical prescription. Sample enrichment of water samples was achieved by solid-phase extraction procedure (SPE), using Waters Oasis HLB cartridges followed by LC-MS-MS. A narrow-bore 2.1 min i.d., reversed phase LC C-18 column was used to chromatograph analytes. Average recoveries from 1 L samples varied 75-95% and the detection limits are <1 ng L-1. The method developed was applied to real samples from wastewater and surface waters of Lazio country (Italy).

引用

页码：263 / 269

页数：7

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