The role of Notch in tumorigenesis: Oncogene or tumour suppressor?

被引：677

作者：

Radtke, F

Raj, K

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

[2] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nrc1186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.

引用

收藏

页码：756 / 767

页数：12

相关论文

共 141 条

[1] Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells [J].

Allman, D ;

Karnell, FG ;

Punt, JA ;

Bakkour, S ;

Xu, LW ;

Myung, P ;

Koretzky, GA ;

Pui, JC ;

Aster, JC ;

Pear, WS .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (01) :99-106

[2] Gli and hedgehog in cancer:: Tumours, embryos and stem cells [J].

Altaba, AR ;

Sánchez, P ;

Dahmane, N .

NATURE REVIEWS CANCER, 2002, 2 (05) :361-372

[3] CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? [J].

Arias, AM ;

Zecchini, V ;

Brennan, K .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (05) :524-533

[4] NOTCH SIGNALING [J].

ARTAVANISTSAKONAS, S ;

MATSUNO, K ;

FORTINI, ME .

SCIENCE, 1995, 268 (5208) :225-232

[5] Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1 [J].

Aster, JC ;

Xu, LW ;

Karnell, FG ;

Patriub, V ;

Pui, JC ;

Pear, WS .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (20) :7505-7515

[6] Interaction between wingless and notch signaling pathways mediated by dishevelled [J].

Axelrod, JD ;

Matsuno, K ;

ArtavanisTsakonas, S ;

Perrimon, N .

SCIENCE, 1996, 271 (5257) :1826-1832

[7] SUPPRESSOR OF HAIRLESS DIRECTLY ACTIVATES TRANSCRIPTION OF ENHANCER OF SPLIT COMPLEX GENES IN RESPONSE TO NOTCH RECEPTOR ACTIVITY [J].

BAILEY, AM ;

POSAKONY, JW .

GENES & DEVELOPMENT, 1995, 9 (21) :2609-2622

[8] THE E6-E7 REGION OF HUMAN PAPILLOMAVIRUS TYPE-18 IS SUFFICIENT FOR TRANSFORMATION OF NIH-3T3 AND RAT-1 CELLS [J].

BEDELL, MA ;

JONES, KH ;

LAIMINS, LA .

JOURNAL OF VIROLOGY, 1987, 61 (11) :3635-3640

[9] Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice [J].

Bellavia, D ;

Campese, AF ;

Alesse, E ;

Vacca, A ;

Felli, MP ;

Balestri, A ;

Stoppacciaro, A ;

Tiveron, C ;

Tatangelo, L ;

Giovarelli, M ;

Gaetano, C ;

Ruco, L ;

Hoffman, ES ;

Hayday, AC ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Screpanti, I .

EMBO JOURNAL, 2000, 19 (13) :3337-3348

[10]

BETTENHAUSEN B, 1995, DEVELOPMENT, V121, P2407

← 1 2 3 4 5 6 7 8 9 10 →