DRUG DEVELOPMENT Locking down metabolism

被引：5

作者：

Bishai, William R. ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Ctr TB Res, Baltimore, MD 21205 USA

来源：

NATURE CHEMICAL BIOLOGY | 2017年 / 13卷 / 09期

关键词：

MYCOBACTERIUM-TUBERCULOSIS; ESSENTIAL GENES; MUTAGENESIS;

D O I：

10.1038/nchembio.2452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

An allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase-an enzyme that is nonessential for in vitro growth-has potent antimicrobial activity, revealing a potentially expanded target list for antimicrobials and greater chemical space for new inhibitors.

引用

页码：925 / 926

页数：3

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