Mitotic force generators and chromosome segregation

被引：57

作者：

Civelekoglu-Scholey, Gul ^{[1
]}

Scholey, Jonathan M. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Mol & Cell Biol, Davis, CA 95616 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 13期

关键词：

Microtubules; Mitotic motors; Mitotic spindle; Kinesins; Force-generation; Force-velocity relationships; KINETOCHORE-MICROTUBULE ATTACHMENT; CROSS-LINKS MICROTUBULES; SEA-URCHIN EGGS; POLEWARD FLUX; CENP-E; SPINDLE ORGANIZATION; IN-VITRO; HOMOTETRAMERIC KINESIN-5; CAENORHABDITIS-ELEGANS; QUANTITATIVE-ANALYSIS;

D O I：

10.1007/s00018-010-0326-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.

引用

页码：2231 / 2250

页数：20

共 154 条

[1]

CHROMOSOME MOTION DURING ATTACHMENT TO THE VERTEBRATE SPINDLE - INITIAL SALTATORY-LIKE BEHAVIOR OF CHROMOSOMES AND QUANTITATIVE-ANALYSIS OF FORCE PRODUCTION BY NASCENT KINETOCHORE FIBERS [J].

ALEXANDER, SP ;

RIEDER, CL .

JOURNAL OF CELL BIOLOGY, 1991, 113 (04) :805-815

[2]

AMOS LA, 1974, J CELL SCI, V14, P523

[3]

BASKIN TI, 1990, J CELL SCI, V97, P79

[4]

Berg H. C, 1993, Random Walks in Biology, DOI DOI 10.1063/1.2819954

[5]

MECHANISM OF ACTION OF COLCHICINE - COLCHICINE BINDING TO SEA URCHIN EGGS AND MITOTIC APPARATUS [J].

BORISY, GG ;

TAYLOR, EW .

JOURNAL OF CELL BIOLOGY, 1967, 34 (02) :535-&

[6]

MECHANISM OF ACTION OF COLCHICINE - BINDING OF COLCHINCINE-3H TO CELLULAR PROTEIN [J].

BORISY, GG ;

TAYLOR, EW .

JOURNAL OF CELL BIOLOGY, 1967, 34 (02) :525-&

[7]

Chromosome motors on the move - From motion to spindle checkpoint activity [J].

Brunet, S ;

Vernos, I .

EMBO REPORTS, 2001, 2 (08) :669-673

[8]

Model for anaphase B: Role of three mitotic motors in a switch from poleward flux to spindle elongation [J].

Brust-Mascher, I ;

Civelekoglu-Scholey, G ;

Kwon, M ;

Mogilner, A ;

Scholey, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15938-15943

[9]

Microtubule flux and sliding in mitotic spindles of Drosophila embryos [J].

Brust-Mascher, I ;

Scholey, JM .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (11) :3967-3975

[10]

Kinesin-5-dependent Poleward Flux and Spindle Length Control in Drosophila Embryo Mitosis [J].

Brust-Mascher, Ingrid ;

Sommi, Patrizia ;

Cheerambathur, Dhanya K. ;

Scholey, Jonathan M. .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (06) :1749-1762

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