Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein

被引：48

作者：

Kim, WK

Tang, Y

Okada, Y

Torrey, TA

Chattopadhyay, SK

Pfleiderer, M

Falkner, FG

Dorner, F

Choi, W

Hirokawa, N

Morse, HC

机构：

[1] NIAID, Immunopathol Lab, LIP, NIH, Bethesda, MD 20892 USA

[2] Univ Tokyo, Grad Sch, Dept Anat & Cell Biol, Tokyo, Japan

[3] Immuno AG Wien, Vienna, Austria

[4] Ajou Univ, Inst Med Sci, Mol Biol Lab, Kyonggi Do, South Korea

[5] Ewha Womans Univ, Seoul, South Korea

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 08期

关键词：

D O I：

10.1128/JVI.72.8.6898-6901.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-assoclated motor protein that belongs to the kinesin superfamily. KTF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.

引用

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页码：6898 / 6901

页数：4

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