Long-term administration of oral low-base topoisomerase II inhibitors, MST-16 and VP-16, for refractory or relapsed non-Hodgkin's lymphoma

It is known that the topoisomerase II inhibitors, MST-16 (sobuzaxane) and VP-16 (etoposide), are effective for the treatment of lymphoma, Five patients with refractory or relapsed non-Hodgkin's lymphoma (NHL) were treated with a combination of oral MST-16 and VP-16 over a long period, Two patients had severely refractory NHL. The remaining 3 patients could not be treated with intensive chemotherapy because of severe organ dysfunction or a poor hematopoietic reserve. All 5 are alive and well after MST-16 and VP-16 treatment, MST-16 and VP-16 are effective for NHL when intensive chemotherapy is ineffective or contraindicated. Copyright (C) 2001 S. Karger AG, Basel.