Pathogenesis of Helicobacter pylori Infection

被引：89

作者：

Basso, Daniela ^{[1
]}

Plebani, Mario ^{[1
,2
]}

Kusters, Johannes G. ^{[3
]}

机构：

[1] Univ Hosp Padova, Dept Lab Med, I-35128 Padua, Italy

[2] Abano Terme Gen Hosp, Leonardo Fdn, Abano Terme, Italy

[3] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

来源：

HELICOBACTER | 2010年 / 15卷

关键词：

Outer membrane proteins; cagA; vacA; babA; GASTRIC EPITHELIAL-CELLS; KAPPA-B; INDUCED APOPTOSIS; NICKEL CHAPERONE; EXPRESSION; CAGA; NUCLEAR; PROTEIN; DNA; ACTIVATION;

D O I：

10.1111/j.1523-5378.2010.00781.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Helicobacter pylori infections are thought to eventually lead to symptoms as a result of the long-lasting interactions between the bacterium and its host. Mechanisms that allow this bacterium to cause a life-long infection involve modulation of both the immune response and host cellular processes. Last year many novel findings that improve our knowledge on how H. pylori virulence factors interact with the host were reported, but because of space limitations we can only discuss a limited number of these studies. Among those are studies on the genetic variation of genes encoding outer membrane proteins and the mimicry of host antigens, factors that alter host-cell metabolism and factors that modulate the host's immune response.

引用

页码：14 / 20

页数：7

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