Brain derived neurotrophic factor circulating levels in patients undergoing IVF

被引：29

作者：

Monteleone, P. ^{[1
]}

Artini, P. G. ^{[1
]}

Simi, G. ^{[1
]}

Cela, V. ^{[1
]}

Casarosa, E. ^{[1
]}

Begliuomini, S. ^{[1
]}

Ninni, F. ^{[1
]}

Pluchino, N. ^{[1
]}

Luisi, M. ^{[1
]}

Genazzani, A. R. ^{[1
]}

机构：

[1] Univ Pisa, Div Obstet & Gynecol, Dept Reprod Med & Child Dev, I-56126 Pisa, Italy

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2007年 / 24卷 / 10期

关键词：

brain derived neurotrophic factor; IVF; ICSI outcome; assisted reproduction; estradiol;

D O I：

10.1007/s10815-007-9169-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose The aim of the study was to measure circulating BDNF levels, a neurotrophin recently identified in the ovary, in parallel with estradiol, to verify if assessing this factor could add any predictive value to the outcome of in vitro fertilization. Methods Blood sampling for BDNF and estradiol was performed in 23 subjects undergoing IVF on day 1 (D1), day 8 (D8), day of HCG administration (DHCG) and day of oocyte retrieval.(DOR). Results There was a positive correlation between BDNF and estradiol throughout the stimulation cycle in all subjects. In both pregnant and nonpregnant patients, the values of BDNF grew significantly only between D8 and DHCG and remained constant until DOR. Between-group comparisons showed no statistically significant differences in both BDNF and estradiol values throughout the IVF cycle. Conclusion Although BDNF plasma concentrations are not seemingly predictive of IVF outcome, this neurotrophin is highly correlated to estradiol levels and seems to be an important factor especially in the periovulatory period.

引用

页码：477 / 480

页数：4

共 16 条

[1]

BEGLIUOMINI S, 2007, IN PRESS HUM REPROD

[2] Should fertilization treatment start with reducing stress? [J].

Campagne, Daniel M. .

HUMAN REPRODUCTION, 2006, 21 (07) :1651-1658

[3] Measuring estradiol levels after human chorionic gonadotropin administration for in vitro fertilization is not clinically useful [J].

Chiasson, Melissa D. ;

Bates, G. Wright ;

Robinson, Randal D. ;

Arthur, Nancy J. ;

Propst, Anthony M. .

FERTILITY AND STERILITY, 2007, 87 (02) :448-450

[4] Effect of gonadotropins on brain-derived neurotrophic factor secretion by human follicular cumulus cells [J].

Feng, B ;

Chen, SL ;

Shelden, RM ;

Seifer, DB .

FERTILITY AND STERILITY, 2003, 80 (03) :658-659

[5] Sex and ovarian steroids modulate brain-derived neurotrophic factor (BDNF) protein levels in rat hippocampus under stressful and non-stressful conditions [J].

Franklin, TB ;

Perrot-Sinal, TS .

PSYCHONEUROENDOCRINOLOGY, 2006, 31 (01) :38-48

[6] Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement [J].

Gibbs, RB .

BRAIN RESEARCH, 1998, 787 (02) :259-268

[7]

LAUFER N, 1986, FERTIL STERIL, V46, P73

[8] Value of estradiol response after human chorionic gonadotropin administration in predicting in vitro fertilization success [J].

Meyer, WR ;

Beyler, SA ;

Baker, ST ;

Somkuti, SG ;

Lowden, DA ;

Grainger, DA .

FERTILITY AND STERILITY, 1999, 72 (03) :542-545

[9] Transport of brain-derived neurotrophic factor across the blood-brain barrier [J].

Pan, WH ;

Banks, WA ;

Fasold, MB ;

Bluth, J ;

Kastin, AJ .

NEUROPHARMACOLOGY, 1998, 37 (12) :1553-1561

[10] Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS [J].

Scharfman, Helen E. ;

MacLusky, Neil J. .

FRONTIERS IN NEUROENDOCRINOLOGY, 2006, 27 (04) :415-435

← 1 2 →