The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals

被引：382

作者：

Logan, M ^{[1
]}

Pagán-Westphal, SM ^{[1
]}

Smith, DM ^{[1
]}

Paganessi, L ^{[1
]}

Tabin, CJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

CELL | 1998年 / 94卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(00)81474-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism by which asymmetric signals induce left-right-specific morphogenesis has been elusive. Pitx2 encodes a transcription factor expressed throughout the left lateral plate mesoderm and subsequently on the left side of asymmetric organs such as the heart and gut during organogenesis in the chick embryo. Pitx2 is induced by the asymmetric signals encoded by Nodal and Sonic hedgehog, and its expression is blocked by prior treatment with an antibody against Sonic hedgehog. Misexpression of Pitx2 on the right side of the embryo is sufficient to produce reversed heart looping and heart isomerisms, reversed body rotation, and reversed gut situs.

引用

页码：307 / 317

页数：11

共 38 条

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