Inositol phospholipids: Translocation, translocation, translocation ...

被引：39

作者：

Irvine, R ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 16期

关键词：

D O I：

10.1016/S0960-9822(07)00360-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pleckstrin homology (PH) domains of a number of proteins have been found to interact in vitro with inositol phospholipids; recent experiments show that these interactions may be important in directing protein translocation to specific parts of the cell following stimulus-induced lipid breakdown or synthesis. (C) Current Biology Publications ISSN 0960-9822.

引用

页码：R557 / R559

页数：3

共 20 条

[1] 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase [J].

Alessi, DR ;

Deak, M ;

Casamayor, A ;

Caudwell, FB ;

Morrice, N ;

Norman, DG ;

Gaffney, P ;

Reese, CB ;

MacDougall, CN ;

Harbison, D ;

Ashworth, A ;

Bownes, M .

CURRENT BIOLOGY, 1997, 7 (10) :776-789

[2] Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B [J].

Anderson, KE ;

Coadwell, J ;

Stephens, LR ;

Hawkins, PT .

CURRENT BIOLOGY, 1998, 8 (12) :684-691

[3] Role of translocation in the activation and function of protein kinase B [J].

Andjelkovic, M ;

Alessi, DR ;

Meier, R ;

Fernandez, A ;

Lamb, NJC ;

Frech, M ;

Cron, P ;

Cohen, P ;

Lucocq, JM ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31515-31524

[4]

CIFUENTES ME, 1994, J BIOL CHEM, V269, P1945

[5] Inositol 1,3,4,5-tetrakisphosphate and Ca2+ homoeostasis: the role of GAPI(IP4BP) [J].

Cullen, PJ ;

LoomisHusselbee, J ;

Dawson, AP ;

Irvine, RF .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1997, 25 (03) :991-996

[6] Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta [J].

Essen, LO ;

Perisic, O ;

Cheung, R ;

Katan, M ;

Williams, RL .

NATURE, 1996, 380 (6575) :595-602

[7] Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting [J].

Falasca, M ;

Logan, SK ;

Lehto, VP ;

Baccante, G ;

Lemmon, MA ;

Schlessinger, J .

EMBO JOURNAL, 1998, 17 (02) :414-422

[8] STRUCTURE OF THE HIGH-AFFINITY COMPLEX OF INOSITOL TRISPHOSPHATE WITH A PHOSPHOLIPASE-C PLECKSTRIN HOMOLOGY DOMAIN [J].

FERGUSON, KM ;

LEMMON, MA ;

SCHLESSINGER, J ;

SIGLER, PB .

CELL, 1995, 83 (06) :1037-1046

[9] Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation [J].

Fluckiger, AC ;

Li, ZM ;

Kato, RM ;

Wahl, MI ;

Ochs, HD ;

Longnecker, R ;

Kinet, JP ;

Witte, ON ;

Scharenberg, AM ;

Rawlings, DJ .

EMBO JOURNAL, 1998, 17 (07) :1973-1985

[10]

HOKIN MR, 1953, J BIOL CHEM, V203, P967

← 1 2 →