Does stimulation of the GPi control dyskinesia by activating inhibitory axons?

被引：134

作者：

Wu, YR

Levy, R

Ashby, P

Tasker, RR

Dostrovsky, JO

机构：

[1] Univ Toronto, Toronto Western Hosp, Playfair Neurosci Unit, Res Inst, Toronto, ON M5T 2S8, Canada

[2] Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada

[3] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[4] Chang Gung Mem Hosp, Dept Neurol 2, Taipei 10591, Taiwan

来源：

MOVEMENT DISORDERS | 2001年 / 16卷 / 02期

关键词：

dyskinesias; deep brain stimulation; globus pallidus internus; parkinsonism;

D O I：

10.1002/mds.1046

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 69-year-old woman with Parkinson's disease and levodopa-induced dyskinesias had a deep brain stimulation (DBS) electrode inserted into the right globus pallidus internus (GPi). During the operation, the GPI was mapped with dual microelectrode recordings. Stimulation through one microelectrode in GPI inhibited the firing of GPi neurons recorded with another microelectrode 600-1.000 mum distant. The inhibition could be obtained with pulse widths of 150 mus and intensities as low as 10 muA. Single stimuli inhibited GPI neurons for similar to 50 ms. Trains of 300 Hz stimuli inhibited GPi neuron firing almost completely. Postoperatively. stimulation through macroelectrode contacts located in the posterior ventral pallidum controlled the patient's dyskinesias. The effect could be obtained with pulse widths of 50 mus and frequencies as low as 70-80 Hz. We postulate stimulation of the ventral pallidum controls dyskinesias by activating large axons which inhibit GPi neurons. (C) 2001 Movement Disorder Society.

引用

页码：208 / 216

页数：9

共 23 条

[1] Immediate motor effects of stimulation through electrodes implanted in the human globus pallidus [J].