Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia

被引：94

作者：

Salmon, E

Garraux, G

Delbeuck, X

Collette, F

Kalbe, E

Zuendorf, G

Perani, D

Fazio, F

Herholz, K

机构：

[1] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

[2] Univ Cologne, Dept Neurol, Cologne, Germany

[3] Max Planck Inst Neurol Res, Cologne, Germany

[4] Univ Vita Salute HSR, INB CNR, Milan, Italy

[5] Milano Bicocca Sci Inst HSR, Milan, Italy

来源：

NEUROIMAGE | 2003年 / 20卷 / 01期

关键词：

D O I：

10.1016/S1053-8119(03)00346-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a multicenter study, FDG-PET images in a population of 29 patients with frontotemporal dementia (FTD) were compared to controls with similar age from each center. A conjunction analysis led to identification of the ventromedial frontopolar cortex as the single region affected in each and every FTD patients. This precise regional metabolic impairment should be integrated with recent neuropsychological researches, such as those showing that the ventromedial frontal cortex is critically involved in decision-making processes based on personal experience, feelings of rightness or social knowledge, processes that are characteristically impaired in FTD. (C) 2003 Elsevier Inc. All rights reserved.

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页码：435 / 440

页数：6

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