Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium

被引：9

作者：

Brown, Jeremy K. ^{[1
]}

Knight, Pamela A. ^{[1
]}

Thornton, Elisabeth M. ^{[1
]}

Pate, Judith A. ^{[1
]}

Coonrod, Scott ^{[2
]}

Miller, Hugh R. P. ^{[1
]}

Pemberton, Alan D. ^{[1
]}

机构：

[1] Univ Edinburgh, Easter Bush Vet Ctr, Div Vet Clin Studies, Roslin EH25 9RG, Midlothian, Scotland

[2] Cornell Univ, Coll Vet Med, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2008年 / 38卷 / 02期

关键词：

enterocyte; Mcpt-1; mMCP-1; mucosa; helminth; rodent;

D O I：

10.1016/j.ijpara.2007.10.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Phospholipase A(2) (PLA(2)) enzymes play a central role in the initiation, propagation and resolution of inflammation. Here, we describe de novo expression of group IVC PLA(2) (PLA2g4c) within the intestinal epithelium of Trichinella spiralis parasitised mice. This mouse mast cell protease-1 sensitive, calcium-independent PLA2 is not detectable in the jejunal epithelium of uninfected mice but becomes highly expressed within the epithelial compartment within days of nematode establishment. We propose that epithelial PLA2g4c accounts for the increased lysophospholipase activity observed during intestinal nematodiasis and that it plays a major role in the inflammatory response to nematodes. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：143 / 147

页数：5

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