Oxaliplatin

被引：217

作者：

Graham, J ^{[1
]}

Muhsin, M ^{[1
]}

Kirkpatrick, P ^{[1
]}

机构：

[1] Decis Resources Int, London WC1B 4HQ, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 01期

关键词：

D O I：

10.1038/nrd1287

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Oxaliplatin (Eloxatin; Sanofi-Synthelabo) is the first platinum-based anticancer drug to be approved for the treatment of colorectal cancer, a major cause of cancer deaths worldwide. Following European approval in 1999, has approval of oxaliplatin by the US FDA in August 2002 set it on the road to becoming a blockbuster?

引用

收藏

页码：11 / 12

页数：2

相关论文

共 8 条

[1]

DEGRAMONT A, 2003, P AN M AM SOC CLIN, V22, P253

[2] Cellular and molecular aspects of drugs of the future: oxaliplatin [J].

Di Francesco, AM ;

Ruggiero, A ;

Riccardi, R .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (11) :1914-1927

[3] A Randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer [J].

Goldberg, RM ;

Sargent, DJ ;

Morton, RF ;

Fuchs, CS ;

Ramanathan, RK ;

Williamson, SK ;

Findlay, BP ;

Pitot, HC ;

Alberts, SR .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (01) :23-30

[4] Structure, recognition, and processing of cisplatin-DNA adducts [J].

Jamieson, ER ;

Lippard, SJ .

CHEMICAL REVIEWS, 1999, 99 (09) :2467-2498

[5] 5-Fluorouracil: Mechanisms of action and clinical strategies [J].

Longley, DB ;

Harkin, DP ;

Johnston, PG .

NATURE REVIEWS CANCER, 2003, 3 (05) :330-338

[6]

Parkin DM, 2001, EUR J CANCER, V37, pS4, DOI 10.1016/S0959-8049(01)00267-2

[7]

Raymond E, 1998, SEMIN ONCOL, V25, P4

[8] Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel [J].

Rixe, O ;

Ortuzar, W ;

Alvarez, M ;

Parker, R ;

Reed, E ;

Paull, K ;

Fojo, T .

BIOCHEMICAL PHARMACOLOGY, 1996, 52 (12) :1855-1865