Regional cerebral blood flow in first-episode schizophrenia patients before and after antipsychotic drug treatment

被引：24

作者：

Livingston, MG ^{[1
]}

McCreadie, RG ^{[1
]}

Bouch, CJK ^{[1
]}

Brown, KW ^{[1
]}

Brown, T ^{[1
]}

Clark, S ^{[1
]}

Corrigan, E ^{[1
]}

Crocket, GT ^{[1
]}

Graham, J ^{[1
]}

Hughson, AVM ^{[1
]}

Hunter, R ^{[1
]}

Kemp, M ^{[1
]}

McKane, J ^{[1
]}

Matson, IC ^{[1
]}

Reid, J ^{[1
]}

Turner, MS ^{[1
]}

Waterhouse, J ^{[1
]}

Williamson, DJ ^{[1
]}

Wood, E ^{[1
]}

Berry, A ^{[1
]}

Caris, HF ^{[1
]}

Dow, MGT ^{[1
]}

Greene, JG ^{[1
]}

Li, CK ^{[1
]}

McGovern, J ^{[1
]}

Mahmood, Z ^{[1
]}

Scott, AM ^{[1
]}

Sim, A ^{[1
]}

Weighill, VE ^{[1
]}

Hadley, D ^{[1
]}

Wiles, D ^{[1
]}

Wyper, DJ ^{[1
]}

Batchelor, DH ^{[1
]}

Rendall, M ^{[1
]}

Hammond, G ^{[1
]}

机构：

[1] Univ Glasgow, Acad Ctr, Gartnavel Royal Hosp, Dept Psychol Med, Glasgow G12 0XH, Lanark, Scotland

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1998年 / 97卷 / 06期

关键词：

schizophrenia; SPECT; first episode; drug treatment;

D O I：

10.1111/j.1600-0447.1998.tb10029.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A total of 38 patients in a first presentation of schizophrenia prior to drug treatment underwent a single photon emission computerized tomography (SPECT) scanning programme whilst undertaking a verbal fluency task. Their scans were compared with those of 38 normal volunteer controls matched for age, sex and father's social class. Schizophrenic patients displayed a trend towards a reduced blood flow in comparison with controls. Comparing right with left hemispheres, asymmetrical blood now patterns were more likely to be found in patients in frontal regions than elsewhere. When 27 of the 38 patients underwent a repeat SPECT scanning programme after receiving 6 months of antipsychotic drug treatment, the hypofrontal blood flow pattern persisted. Increased blood now was observed bilaterally in the putamen. The more symmetrical blood flow pattern of the patients compared to the control subjects did not alter substantially.

引用

页码：440 / 449

页数：10

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