Current issues in mutagenesis and carcinogenesis .67. IPCS harmonization of methods for the prediction and quantification of human carcinogenic/mutagenic hazard, and for indicating the probable mechanism of action of carcinogens

被引：39

作者：

Ashby, J

Waters, MD

Preston, J

Adler, ID

Douglas, GR

Fielder, R

Shelby, MD

Anderson, D

Sofuni, T

Gopalan, HNB

Becking, G

SonichMullin, C

机构：

[1] ZENECA CTL,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND

[2] US EPA,NHEERL,RES TRIANGLE PK,NC 27711

[3] CIIT,RES TRIANGLE PK,NC 27709

[4] GSF FORSCHUNGSZENTRUM UNWELT & GESUNDHEIT GMBH,D-85758 OBERSCHLEISSHEIM,GERMANY

[5] CTR ENVIRONM HLTH,OTTAWA,ON K1A 0L2,CANADA

[6] DEPT HLTH,DIV HEF,LONDON SE1 6LW,ENGLAND

[7] NIEHS,RES TRIANGLE PK,NC 27709

[8] BIBRA INT,CARSHALTON SM5 4DS,SURREY,ENGLAND

[9] NATL INST HLTH SCI,BIOL SAFETY RES CTR,DIV GENET & MUTAGENESIS,SETAGAYA KU,TOKYO 158,JAPAN

[10] UNEP,NAIROBI,KENYA

[11] WHO,PCS,IRRU,RES TRIANGLE PK,NC 27709

[12] WHO,PCS,ARM,CH-1211 GENEVA,SWITZERLAND

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 352卷 / 1-2期

关键词：

D O I：

10.1016/0027-5107(95)00221-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A flow chart is presented as a recommended sequence of tests to predict the carcinogenic hazard, and to predict and quantify the mutagenic hazard to germ cells of chemicals to humans. Ten associated principles of testing for these endpoints are also suggested. These recommendations are the result of a meeting convened under the auspices of the International Programme on Chemical Safety (IPCS), as part of their project on 'Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals'. The meeting was held at Carshalton, Surrey, from 13-17 February 1995.

引用

页码：153 / 157

页数：5