General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

被引：143

作者：

Kim, Justin ^{[1
]}

Movassaghi, Mohammad ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 41期

关键词：

CONCISE TOTAL-SYNTHESIS; GLIOTOXIN; ANALOGS; EPIDITHIODIOXOPIPERAZINES; DEHYDROGLIOTOXIN; VERTICILLIN; METABOLITE; CHAETOCIN;

D O I：

10.1021/ja106869s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathiodiketopiperazines.

引用

页码：14376 / 14378

页数：3

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