Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections

被引：137

作者：

Arora, SK

Neely, AN

Blair, B

Lory, S

Ramphal, R

机构：

[1] Univ Florida, Dept Med Infect Dis, JHMHC, Gainesville, FL 32610 USA

[2] Shriners Hosp Children, Cincinnati, OH USA

[3] Harvard Univ, Sch Med, Dept Microbiol, Boston, MA USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 07期

关键词：

D O I：

10.1128/IAI.73.7.4395-4398.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.

引用

收藏

页码：4395 / 4398

页数：4

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